Document Type : Original Article
Department of nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
Herbal Medicine Research Center (HMRC), Pharmaceutical Branch, Islamic Azad University, Tehran, Iran.
Zinc sulfide (ZnS) & zinc oxide (ZnO) nanoparticles was evaluated for their antimicrobial activity against four pathogenic strains. ZnS&ZnO nanoparticles were synthesized by simple aqueous chemical reaction in an aqueous solution. The main advantage of these nanoparticles (size of 10-30 nm) was that simply could be prepared by using cheap precursors in a cost effective and high throughput manner. Structural, morphological and chemical composition of the prepared nanoparticles were investigated by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and energy dispersion X-ray dispersive fluorescence spectroscopy (EDAX). The antimicrobial effects of the ZnS&ZnOnanoparticls were studied by serial dilution technique and also by well diffusion technique against four pathogenic microorganism strains of Staphyloccusaureus, Escherichia coli, Pseudomonas aeroginosa and Candidiaalbicans. Both nanoparticles of ZnS&ZnO showed antimicrobial activity against both Gram positive Staphyloccusaureus and Gram negative Escherichia coli and Pseudomonas aeroginosa and fungi of Candidiaalbicans. The best antimicrobial efficacy (as MIC of 50 µg/ml) was related to effect of ZnO nanoparticles on Staphyloccusaureus and most resistant pathogen was Candidiaaibicans against ZnS nanoparticles with MIC more than 250 µg/ml. Zinc sulfide (ZnS) & zinc oxide (ZnO) nanoparticles was evaluated for their antimicrobial activity against four pathogenic strains. ZnS&ZnO nanoparticles were synthesized by simple aqueous chemical reaction in an aqueous solution.