Preparation and In vitro Characterization of Alprazolam Extended- Release Tablets Using HPMC 4000cps

Document Type: Short Communication


1 Department of Nanotechnology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran

2 Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran


The main aim of this study was preparation and evaluation of extended - release system of
the anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties
similar to those of diazepam. Our studies focused on development of extended drug delivery
system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and
Polyvinylpyrrolidone (PVP k30) as binder using factorial design. All prepared matrix tablets
were considered for physicochemical evaluation and drug content. In vitro release study of
matrix tablets for all formulations has shown that HPMC is the main component in retarding of
alprazolam in dissolution medium. The optimum formulation (30% HPMC 4000 and 10% PVP)
with suitable release profile according to criteria of United State Pharmacopoeia has selected for
stability studies according to ICH guidelines.