Design and Synthesis of New Biarylhydrazides Possessing an Azido Pharmacophore as Selective COX-2 Inhibitors

	Design and Synthesis of New Biarylhydrazides Possessing an Azido Pharmacophore as Selective COX-2 Inhibitors
Article 5, Volume 1, Issue 4, Summer 2013, Page 267-272 PDF (522.6 K)
Document Type: Original Article
Abstract
A group of 1,3-biarylhydrazide derivatives possessing a COX-2 azido pharmacophore at the Para- position of the C-1 phenyl ring in conjunction with a N-3 phenyl or substituted-phenyl ring (4-F,4-Cl,4-OMe) were designed and synthesized based on nucleophilic substitution reaction. A molecular modelling study of these compounds showed that the designed molecules were well bound with the active site of COX-2 enzyme and the N3 pharmacophore was well oriented into the COX-2 secondary pocket. Thus, we expect the compounds show good potency and selectivity on COX-2 inhibition.
Keywords
Azido Pharmacophore; COX-2 inhibitors; Hydrazide Moiety
Main Subjects
Medicinal chemistry


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