Document Type : Original Article
A simple extractive spectrophotometric method has been developed for the estimation of miconazole nitrate
in both pure and pharmaceutical preparation. The method is based on the formation of ion-pair complex of the
drug with acidic dye bromothymol blue (BTB) in acidic condition, followed by its extraction in organic solvent
(chloroform). The absorbance was measured against the corresponding blank. The maximum absorbance
was found at 434 nm. Linear calibration graph was obtained in the concentration range 1-35 μg ml-1. The
method was validated statistically. Recovery studies gave satisfactory results indicating that none of common
additives and excipients interfere the assay method. The proposed methods were found to be simple, accurate nd reproducible and their performance in analysis of cream formulation was successfully examined.