The Effect of Vitamin C and E Supplementation on CRP, IL- 6, Lymphocyte,Cortisol and Lactate Response Following one Aerobic Training Session

Document Type: Original Article


Introduction: The aim of this research was to compare the effect of a 15-day vitamin C and E
supplementation on C reactive protein (CRP), interleukin- 6 (IL-6), cortisol, lymphocyte, and
lactate response to a single aerobic training session. Methods: Thirty male college students of
Islamic Azad University-Fars Science and Research Branch of with mean age of 21/53±2/99
years, weight 70/03±10/52 kg and height 176±5/97 cm voluntarily contributed in this research.
First aerobic power of all subjects was estimated and the data was used to divide the subjects
into three 10-persons groups (vitamin C group, vitamin E group and placebo group). A matched
study design was used; hence, all target variables were measured before and after the treatment
after the subject ran for 30 minutes on treadmill intensity of 75. The data was analyzed using
ANOVA, ANOVA repeated measure and dependent t test with bonferroni adjustment (p ≤ 0.05).
Findings: Results showed that the 15-days vitamin C and E supplementation had no significant
effect on the level of CRP, IL-6, cortisol, lymphocyte, and lactate at rest, after exercise and one
hour after exercise. Conclusion: Further research is required to explore the impact of vitamin
C/E administration on the level of CRP, IL-6, cortisol, lymphocyte, and lactate in different
exercise conditions, using higer doses of these substances.