• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Journal of Pharmaceutical & Health Sciences
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 6 (2018)
Volume Volume 5 (2017)
Volume Volume 4 (2016)
Volume Volume 3 (2015)
Volume Volume 2 (2013-2014)
Volume Volume 1 (2012-2013)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
heidari, M. (2012). The effects of Tilia platphyllos scop. extract on seizure induced by picrotoxin and pentylentetrazole in mice. Journal of Pharmaceutical & Health Sciences, 1(1), 17-24.
mahmoud reza heidari. "The effects of Tilia platphyllos scop. extract on seizure induced by picrotoxin and pentylentetrazole in mice". Journal of Pharmaceutical & Health Sciences, 1, 1, 2012, 17-24.
heidari, M. (2012). 'The effects of Tilia platphyllos scop. extract on seizure induced by picrotoxin and pentylentetrazole in mice', Journal of Pharmaceutical & Health Sciences, 1(1), pp. 17-24.
heidari, M. The effects of Tilia platphyllos scop. extract on seizure induced by picrotoxin and pentylentetrazole in mice. Journal of Pharmaceutical & Health Sciences, 2012; 1(1): 17-24.

The effects of Tilia platphyllos scop. extract on seizure induced by picrotoxin and pentylentetrazole in mice

Article 2, Volume 1, Issue 1, Autumn 2012, Page 17-24  XML PDF (1.21 MB)
Document Type: Original Article
Author
mahmoud reza heidari*
Abstract
The effects of Tilia plathphyllos scop. in a nervous disorder, including seizure was reported in traditional literatures. In the present investigation, the effects of methanolic extract of T. plathyphyllos on seizure induced by picrotoxin and pentylentetrazole were studied in mice. In this experimental study, groups of 5 animals pretreated with doses of 100, 200 and 300 mg/kg of methanolic extract of flowering branches of T. plathyphyllos, via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10 mg/kg or pentylentetrazole 80 mg/kg intraperitoneally, for induction of seizure. Latency of seizure, death time and percent of death were determined in treated and control groups. The latency of seizure induce by picrotoxin were increased in groups that pretreated with doses of 100 and 200 mg/kg of T. plathyphyllos extract, from 208 Sec to 298(p<0.05) and 570 Sec (p<0.01) respectively. The latency of seizure induced by pentylentetrazole were increased with dose of 200 mg/kg, from 233 Sec to 351 Sec (p<0.01). The dose of 200 mg/kg of extract delayed the death time induced by picrotoxin from 1237 to 1498 Sec ( p<0.05) and pentylentetrazole from 1973 to 2508 Sec (p<0.01). In additin the percentage of mortality from seizure induced by picrotoxin and pentylentetrazole from 100% were decreased to 80% (p<0.05) and 40% (p<0.01) respectively.
Methanolic extract of flowering branches of T. plathyphyllos delayed the onset of seizure, death time and decreased the percentage of mortality from picrotoxin and pentylentetrazole. Further studies are needed to use this plant as an antiseizure agent.
Keywords
Tilia plathyphyllos Scop; Seizure; Picrotoxin; Pentylentetrazole
Statistics
Article View: 2,055
PDF Download: 1,387
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Creative Commons

Your use of the material available on JPHS.ir is licensed under the Creative Commons Attribution 4.0 International (CC-BY 4.0) License. Web Analytics Clicky

Pharmaceutical Sciences  Research Center
Pharmaceutical Sciences Branch
Islamic Azad University
Tehran, Iran
Postal Code: 194193311

P.O. Box:193956466

Tel: +98 21 22006221
Fax: +98 21 22600099

Email: jphs@iaups.ac.ir

Journal Management System. Designed by sinaweb.